Afterlife: Wandering Souls is one of my favorite games I've played. The setting is rich and mysterious and the character creation is compelling and engaging. The art is beautiful and strange. I've run this game for a number of folks now and consistantly they comment on how easy it was to pick up and how much they want to play it again.
The system that Angry Hamster developed for this game is simple, really stripped down to the core of what works. You can see elements of other games in it but the way those ingredients come together is, I think, something pretty unique and really fun to use.
If you're the type of person that likes to chop games up and mix them around, there's a lot of ideas you could easily lift out of Afterlife and use as inspiration for other games. The variety of types of gameplay possible is huge but its all unified by a central theme of discovery, adventure and reflection.
All in all, can't recommend this game enough.
[5 of 5 Stars!]