Fate Core is currently my favorite roleplaying game system! It really can handle just about any setting. We've done postapocalyptic, pulp, space epics, superheroes, steampunk, and so on (I still have a hard time running horror, but that may just be me). The ability to handle any scene without looking up some peculiar rule (I'm looking at you grapple) is a godsend! The game really sings if you get buy-in from everybody at the table and they push the system to its fullest.