I've bought every iteration since the original boxed set and I like Red a lot, but I do have some major issues.
First the good. The combat and netrunning mechanics are, in my opinion, much improved. Combat is more streamlined, although at the cost of some color, and netrunning is more easily integrated into meat world action.
For me, the worst aspect is the actual rulebook. The pages are slick and glossy but feel very fragile and do tear easily. This characteristic is compounded by the fact that the rulebook's organization will have you constantly flipping back and forth. If you have the digital version, the fragility of physical pages won't be an issue, but have fun constantly scrolling through pages.
If you love cyberpunk, buy this game, just be prepared to hate your rulebook.
[4 of 5 Stars!]