Fuzion is a good system. First let me get that out. It is a versitile and effective system for a wide variety of games, and I personally think that its potential has been underplayed for a wide variety of reasons. If you know R. Talsorian's old house system, then you know a good portion of the Fuzion system already. The Hero system did not add so much as alter.
That being said, I would point out that this is a disappointing buy. It would be worth the three bucks I shelled out for it, except that half of the material is available for free online. Character creation, most of the task resolution and combat system, and most of the environmental hazard and recovery systems are reprints from that source.
There is some new material. The expanded lists of example equipment is nice; it beats the generic equipment lists provided in the free online rules. There are also powers systems which are missing in the most recent online rules (but present in earlier versions). However, if you want to use powers, I recommend you don't use the systems in this supplement.
Psionics, magic, and "clerecy" (being a cleric) all work on identical systems. Granted, these days I seem to be in a minority when I say that this is a bad way of handling these powers types. Superpowers work on a similar, but not identical system.
The other major problem they have is misuse of the "multi-genre" concept. A generic system is powerful, but the examples of play (and a good portion of the artwork) involve genre-bending and genre-mixing, without any real mention of actually playing in a single genre and sticking to it.
My reccomendation: use Fuzion. It is a good system. But don't buy this. Go online and find the free versions, and find some of the free supplements which are all over the place (Fists of Fuzion, Power Core, etc.). Some of them are really excellent, and you'll be three bucks richer and equipped with better systems for handling the oddities in every setting.