I had the opportunity of playing it this year at Gen Con and it is a GREAT GAME. I am used to more detailed, super-structured RPGs, where you have rules for everything, and most of your time is spent either tweaking your character or looking for the appropriate rule in one of the books. In Demon Hunter, there is a stronger emphasis in the Role-Playing aspect of the game, rather than in getting the right rule for the right circumstance. An added bonus to the system is the cool background story that comes along with it. The setting is a cool mixture between Buffy, Men In Black, Supernatural and the X Files (Urban Horror) but with a touch of humor.
If you are looking for system that deviates from the more "mainstream" systems, I strongly recommend you to check this system out. You will be pleasantly surprised by it!!