This book is expensive for a PDF, so I was worried about getting bang for my buck. I shouldn't have worried.
Progenitor is an Earth-like setting, so it rides on the strength of its NPCs and its timeline. The NPCs are simply astounding, very well-written and put together. The timeline (and thus the actions of those NPCs) really works well, and makes a lot of sense. The whole setting hangs together very well.
If you play or run Wild Talents, this is a must-have. If you don't mind doing a little adaptation from their system to your favorite, it's probably still worth buying. I had some extra cash lying around, and picked it up just to read - it was totally worth it.
[5 of 5 Stars!]