Disclosure: I backed D6xD6 on Kickstarter.
I grew up playing AD&D, Gamma World, Traveller, Twilight: 2000, Shadowrun, Star Wars, Call of Cthulhu (all-time favorite!), and other RPGs. As a player I have come to dislike memorizing voluminous complex rules, drawing intricate plans for spaceships/tank platoons/etc on graph paper, and the "stat monster" approach which encourages players to obsess about experience points needed to reach the next character level or obtaining some magical item that will incrementally up their armor class.
What I value is storytelling, camaraderie, and any game that shares those goals. I'm happy to say D6xD6 is a such a game. The game's primary mechanism of "Focus" is unique, elegant, and deceptively simple. It makes for rich decisions during the quick character creation phase...do you want to be an incredible expert in one or two areas, a jack-of-all-trades, or something in-between? It feels equally rich when attempting tasks during gameplay. The dice rolling aspect is quick, fun, and suspenseful. While some reviewers commented it was a bit complex, I found it easier than adding up a laundry list of modifiers to my attack (for instance) while my opponent does the same with their defense modifiers, and then comparing results, calculating ripostes, etc etc. D6xD6 gameplay is fast, fun, and keeps the focus on the story.
Some RPGs lean heavily on the tone of their genre/fictional world to carry a player's interest, counting on that to plaster over mediocre game mechanics. D6xD6 is the opposite; at its heart is an excellent set of well-constructed rules that enable players to explore any genre or world setting they choose. I really like this approach and appreciate the variety of Worlds in the Core Book (with many more from famous fiction authors apparently on the way!).
One final thought for those of you reading these reviews while considering a purchase. It is impossible to fully understand and appreciate any game without playing it. You've probably found this in your own gaming experiences. Perhaps you've been surprised that a game sounded really cool but didn't feel right during play. Or maybe you thought the rules seemed a little complex but made so much sense during gameplay. Good game designers are familiar with this effect, too. It's why they don't just write a bunch of rules and chuck it out into the marketplace. They conduct extensive playtesting with real players, make adjustments to the rules, and do it all again.
Some reviewers have not played D6xD6, much less read the entire set of rules, but are sharing lots of opinions. Other reviewers like me have actually played the game multiple times and really enjoyed it. You decide which approach is right for you.
[5 of 5 Stars!]