Been playing this with my usual gaming group using a home-made mashup of Dead Simple and Savage Worlds rules. We have played it as a Saturday morning serial type pulp adventure and had a great time. We have played 5 sessions and not even got to Mars yet! The players were having an unexpectedly good time shmoozing with the other passengers on the Princess Alexandra so I let them get on with it.
Some of the story ideas in the book would not work with the party I have, but it was easy to make up appropriate storylines just from reading the passenger list and imagining what they would get up to.
Space 1889 has some fantastic background material for very little cost and I will be chucking some of that in as I go along with this campaign. There is easily enough material to keep going for years if we want to. And we just might...